• <cite id="d15zv"><span id="d15zv"></span></cite>
    <tt id="d15zv"></tt>

      <tt id="d15zv"><span id="d15zv"></span></tt>

        <cite id="d15zv"></cite>

        首頁» 學術交流» 學術來訪
        學術交流
        學術來訪

        北京大學納米科技論壇系列報告之118講

        報告題目:Electron Transfer Regulation in Tetraheme Cytochromes Revealed by NMR
        報告人:    Prof. Hideo Akutsu
             Osaka University
            Yokohama City University
        地    點:北京大學化學學院A717學術報告廳
        時    間:2019年05月13日(星期一) 上午10:00
        主請人:劉忠范 院士

        報告摘要:

        Cytochromes are ubiquitous heme-proteins that are involved in a wide variety of redox reactions in biological electron transport systems. Some cytochromes have multiple hemes, generally protoporphyrins coordinated to iron. They are mainly found in bacteria that can be traced back more than 500 million years to the anaerobic world, and reveal special redox features because of heme-heme interactions. Such features will be discussed in this talk focusing on c-type tetraheme-cytochromes [1, 2]. A cyclic heme architecture and its environment including bis-imidazole coordination and heme exposure realize extremely low redox potentials of cytochrome c3. To elucidate its mechanism, the effect of extensive mutations at conserved and non-conserved aromatic residues on the coordination property of heme irons was investigated, using NMR and X-ray crystallography [2]. The results suggested the importance of p-p interaction and p-cation interactions among hemes and conserved aromatic rings. On determination of heme reduction potentials, each heme in cytochrome c3 was expected to play a different role in the electron transport with other redox proteins. It was supported by the interaction with [NiFe] hydrogenase. Design of the heme architecture is also important. In contrast to cytochrome c3, the chain-like heme architecture in Shewanella small tetraheme cytochrome c provides a pathway for directional electron transfer. Actually, soluble fumarate reductase visualizes a directional electron transfer through a molecular wire. Thus, the tetraheme architectures can work as sophisticated devices.

        References:

        1) H. Akutsu and Y. Takayama, Functional roles of heme architecture and its environment in tetraheme cytochrome c, Accounts Chem. Res., 40, 171-178 (2007).  

        2) Y. Takayama, M. Taketa-Sato, H. Komori, K. Morita, S.-J. Kang, Y. Higuchi, and H. Akutsu, Role of p-electron systems in stabilization of the oxidized tetraheme architecture in cytochrome c3, Bull. Chem. Soc. Jpn., 84, 1096-1101 (2011).

        Copyright(c)版權所有 北京大學納米化學研究中心 北京市海淀區成府路202號 北京大學化學與分子工程學院A區4層 100871 010-62757157
        最后更新日期:201828 網站統計:
        超级牛牛 www.kyoteam.com:安乡县| www.rippan.com:丰城市| www.salsa-101.com:丘北县| www.stevebayer.com:勐海县| www.judaicaboutique.com:清河县| www.52aiqing.com:达尔| www.crowdcomputingblog.com:新宁县| www.fitnessghost.com:柳河县| www.wwwhg9227.com:湖南省| www.non-league.net:阿图什市| www.yongbeikeji.cn:齐齐哈尔市| www.borealmatters.org:田林县| www.999yingcheng.com:视频| www.rememberforeverphotography.com:商城县| www.lee4mayor.com:勐海县| www.ramblingabare.com:楚雄市| www.mfqnc.com:红河县| www.carakesehatan.com:简阳市| www.gf996.com:宣汉县| www.fuwudai.com:龙岩市| www.ynsh9188.com:砀山县| www.lnkqxx.com:疏勒县| www.tinytoonkidswear.com:本溪| www.aboutren.com:中牟县| www.npyczc.com:建德市| www.1212312.com:铜梁县| www.nation-wide-building.com:砀山县| www.hghx.org:南华县| www.ks-diaz.com:嘉善县| www.foothill-bible.org:福海县| www.012559.com:永吉县| www.acmap2019.com:平罗县| www.allnaturessafeway.com:宁阳县| www.djmix8.com:安溪县| www.dzbcw.com:长汀县| www.mfjqs.com:玉山县| www.yaonvguan.com:漳州市| www.new-vibrations.com:罗山县| www.woodenfences.org:长乐市| www.therasmusfc.com:新昌县| www.eicsamexico.com:克山县| www.180xu.com:新竹市| www.weijinying.com:赞皇县| www.0577gf.com:紫云| www.cm966.com:龙门县| www.sqctwh.com:瑞安市| www.lmpzw.cn:民和| www.zybolimian888.com:古蔺县| www.cafeavec.com:措勤县| www.myqccoupons.com:东阳市| www.koreanista.net:富平县| www.speed28.com:苗栗县| www.jlkyp.com:皮山县| www.yingchuanglaw.com:全南县| www.yusxaf.com:青岛市| www.zibohonglu.com:县级市| www.webgradus.com:黄平县| www.imitrexinfo.org:两当县| www.vip666b.com:大邑县| www.garanit.com:蓬莱市| www.yingchuanglaw.com:浦北县| www.f5696.com:冷水江市| www.vsassociatesbiz.com:东安县| www.2nbe.com:通道| www.jnhb365.net.cn:晋宁县| www.463507.com:漳平市| www.story-of-us.com:保亭| www.pbpnk.com:仙居县| www.sznks.com:宣汉县| www.masterdealzone.com:安阳市| www.sanwencaipiao.com:平遥县| www.re-cyclers.com:威海市| www.0527tm.com:民勤县| www.best-wpthemes.com:龙南县| www.jd-lx.com:六安市| www.z9867.com:曲靖市| www.jsljl.com:得荣县| www.oldschoolvans.com:民勤县| www.awov.org:吐鲁番市| www.cn-ourui.com:黎川县| www.bisutekirevere.com:贵州省| www.agnum100.com:桐柏县| www.gthforex.com:营口市| www.wxxxwl.com:察隅县|